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Adjuvant Therapy for Resected Biliary Tract Cancer: ASCO Clinical Practice Guideline

原文:2019年 发布于 Journal of Clinical Oncology 37卷 第12期 1015-1027 浏览量:298 原文链接

作者: American Society of Clinical Oncology

归属分类: 所属人体系统: 消化 | 分类: 胆管肿瘤

关键词: Biliary Tract Cancer Adjuvant Therapy Guideline

指南简介

Purpose: To develop an evidence-based clinical practice guideline to assist in clinical decision making for patients with resected biliary tract cancer.

Methods: ASCO convened an Expert Panel to conduct a systematic review of the literature on adjuvant therapy for resected biliary tract cancer and provide recommended care options for this patient population.

Results: Three phase III randomized controlled trials, one phase II trial, and 16 retrospective studies met the inclusion criteria.

Recommendations: Based on evidence from a phase III randomized controlled trial, patients with resected biliary tract cancer should be offered adjuvant capecitabine chemotherapy for a duration of 6 months. The dosing used in this trial is described in the qualifying statements, while it should be noted that the dose of capecitabine may also be determined by institutional and regional practices. Patients with extrahepatic cholangiocarcinoma or gallbladder cancer and a microscopically positive surgical resection margin (R1 resection) may be offered chemoradiation therapy. A shared decision-making approach is recommended, considering the risk of harm and potential for benefit associated with radiation therapy for patients with extrahepatic cholangiocarcinoma or gallbladder cancer. Additional information is available at www.asco.org/gastrointestinal-cancer-guidelines .