Pancreatic cancer(PC) remains one of the most challenging malignant tumor in gastrointestinal cancer, and the incidence and mortality rates are significantly increased in the past decades. The 5-years survival rate of PC is less than 8% since its dormant clinical symptoms and lacking of sensibility and specificity markers in early diagnosis. The early diagnosis of pancreatic cancer is a worldwide problem, and the early diagnosis rate is only 5%. Increasing early diagnosis rate is the key to improve the overall prognosis of pancreatic cancer. The key of early diagnosis and treatment of pancreatic cancer is to identify the high-risk population of pancreatic cancer, improve the sensitivity and specificity of early diagnosis technology, standardize the process of early diagnosis of pancreatic cancer, and standardize the treatment of early pancreatic cancer. To this end, this expert consensus is formulated.