medical guideline

Histopathological Diagnosis of Tumour Deposits in Colorectal Cancer: a Delphi Consensus Study

原文:2021年 发布于 Histopathology 浏览量:43 原文链接


归属分类: 所属人体系统: 消化 | 分类:结直肠肿瘤

关键词: TNM System Colorectal Cancer Histopathology Staging Tumour Deposits


Introduction: Tumour deposits (TDs) are an important prognostic marker in colorectal cancer. However, the classification, and inclusion in staging, of TDs has changed significantly in each TNM Edition since their initial description in TNM 5, and terminology remains controversial. Expert consensus is needed to guide the future direction of precision staging.

Methods: A modified Delphi consensus process was used. Statements were formulated and sent to participants as an online survey. Participants were asked to rate their agreement with each statement on a 5-point Likert scale and also to suggest additional statements for discussion. These responses were circulated, together with anonymised comments, and statements were modified prior to carrying out a second online round. Consensus was set at 70%.

Results: Overall, 32 statements reached consensus. There were concerns that TDs were currently incorrectly placed in the TNM system and that their prognostic importance was being underestimated. There were concerns about interobserver variation and it was felt that a clearer, more reproducible definition of TDs was needed.

Conclusions: Our main recommendations are that the number of TDs should be recorded even if LNMs are also present and that nodules with evidence of origin (EMVI, PNI, LI) should still be categorised as TDs and not excluded as TNM 8 specifies. Whether TDs should continue to be included in the N category at all is controversial and did not achieve consensus, however participants agreed that TDs are prognostically worse than LNMs and the N1c category is suboptimal as it does not reflect this.