medical guideline

Improving Tumor Budding Reporting in Colorectal Cancer: a Delphi Consensus Study

原文:2021年 发布于 Virchows Archiv 浏览量:297 原文链接

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归属分类: 所属人体系统: 消化 | 分类: 结直肠肿瘤

关键词: Colorectal Cancer Delphi Study ITBCC Tumor Budding

指南简介

Tumor budding is a long-established independent adverse prognostic marker in colorectal cancer, yet methods for its assessment have varied widely. In an effort to standardize its reporting, a group of experts met in Bern, Switzerland, in 2016 to reach consensus on a single, international, evidence-based method for tumor budding assessment and reporting (International Tumor Budding Consensus Conference [ITBCC]). Tumor budding assessment using the ITBCC criteria has been validated in large cohorts of cancer patients and incorporated into several international colorectal cancer pathology and clinical guidelines. With the wider reporting of tumor budding, new issues have emerged that require further clarification. To better inform researchers and health-care professionals on these issues, an international group of experts in gastrointestinal pathology participated in a modified Delphi process to generate consensus and highlight areas requiring further research. This effort serves to re-affirm the importance of tumor budding in colorectal cancer and support its continued use in routine clinical practice.